THORNE - 5-MTHF - Metilfolato (Folato Activo B9) - 60 Cápsulas - 1 mg

What is 5-MTHF (methylfolate) and why is it important?

5-MTHF, also known as methylfolate or L-methylfolate, is the biologically active form of folate (vitamin B9). Unlike synthetic folic acid, methylfolate does not require conversion in the liver to be utilized by the body. This makes it an especially relevant option for individuals with genetic variants in the MTHFR enzyme, who may have difficulty converting folic acid into its active form.

Folate plays a fundamental role in numerous bodily processes, including DNA synthesis, cell division, and homocysteine metabolism. By directly providing methylfolate, the body's methylation cycle is supported, a key process for neurotransmitter production, detoxification, and the regulation of gene expression.

Benefits of methylfolate according to the EFSA

The European Food Safety Authority (EFSA) has approved several health claims for folate, which also apply to methylfolate. These include:

• Folate contributes to maternal tissue growth during pregnancy.
• Folate contributes to normal blood formation.
• Folate contributes to normal homocysteine metabolism.
• Folate contributes to the normal function of the immune system.
• Folate contributes to the reduction of tiredness and fatigue.

These benefits are scientifically supported and are part of the Community register of nutrition and health claims. It is important to remember that food supplements should not be used as a substitute for a balanced and varied diet.

Recommended daily dose: how much to take?

The usual dose of methylfolate in supplements is 400 to 800 µg daily for the general population. However, this THORNE product provides 1 mg (1000 µg) per capsule, a suitable dose for those who need a higher intake, such as women planning a pregnancy or during the 1st trimester. Spanish health authorities recommend 400 µg of folate daily before and during pregnancy. If you are pregnant or breastfeeding, consult your healthcare professional before taking any supplement.

It is recommended to take one capsule daily, preferably with a meal for better absorption.

Is methylfolate better than traditional folic acid?

Methylfolate (5-MTHF) is the active form of folate, while folic acid is the synthetic form that must be converted in the body. For people with the MTHFR mutation (present in a significant percentage of the population), this conversion can be inefficient. In these cases, methylfolate offers an advantage by being directly usable.

Studies suggest that methylfolate may be more effective in raising blood folate levels and reducing homocysteine. However, it cannot be stated that it is superior for the entire population; each person has different needs. If you have doubts about which form to choose, consult a healthcare professional.

Who is this supplement suitable for?

This methylfolate supplement may be useful for:

• Women of childbearing age, especially those planning a pregnancy or who are pregnant.
• People with high homocysteine levels.
• Individuals with MTHFR genetic variants that affect folic acid conversion.
• Those looking to support cardiovascular and nervous health.
• People following restrictive diets or with low folate intake.

THORNE is a brand recognized for its quality and rigor; its products undergo multiple analytical tests. This supplement is gluten-free, lactose-free, and soy-free, and is suitable for vegetarians.

Frequently asked questions

Can I take methylfolate with other supplements?

Yes, methylfolate usually combines well with other B vitamins, especially B12 and B6, to support homocysteine metabolism. However, if you are taking medication, consult your doctor.

How long does it take to notice the effect?

The effects may vary depending on the person and individual needs. Generally, blood folate levels increase within a few weeks, but the perception of benefits such as reduced fatigue may be gradual.

Food supplements should not be used as a substitute for a balanced diet. Do not exceed the recommended daily dose. Keep out of reach of young children.