{"product_id":"her-2-la-creacion-de-herceptin-tratamiento-revolucionario-cancer-de-mama-0812991842","title":"Her-2: The creation of Herceptin, a revolutionary breast cancer treatment","description":"\u003ch2\u003eHow did Herceptin, a revolutionary breast cancer treatment, come about?\u003c\/h2\u003e\u003cp\u003eThe book \"Her-2: The Making of Herceptin\" narrates the exciting scientific and human story behind the development of Herceptin, a drug that changed the prognosis of HER2-positive breast cancer. Written by science journalist Robert Bazell, the work combines research, testimonies, and a detailed account of the advances that led to this targeted therapy. Published by Random House, it has been critically acclaimed for its rigor and ability to disseminate information. Although it is not a self-help book or a medical manual, it is of great interest to patients, family members, and professionals who wish to understand how science can transform the fight against cancer.\u003c\/p\u003e\u003ch2\u003eScientific context: the discovery of the HER2 oncogene\u003c\/h2\u003e\u003cp\u003eIn the 1980s, researchers identified that a protein called HER2 is overexpressed in approximately 20-25% of breast cancers, associating with a more aggressive form of the disease. The book clearly explains how this finding opened the door to the development of a monoclonal antibody capable of blocking the growth signal of tumor cells. Bazell details the pioneering work of scientists like Dennis Slamon and the role of the pharmaceutical industry in the creation of Herceptin (trastuzumab). He also addresses the biological foundations of monoclonal antibodies and why they represented a paradigm shift in oncology.\u003c\/p\u003e\u003ch2\u003eThe long road from laboratory to approval\u003c\/h2\u003e\u003cp\u003eThe work covers more than ten years of research, clinical trials, and regulatory obstacles until Herceptin was approved by the FDA in 1998 for the treatment of HER2-positive metastatic breast cancer. Technical challenges, controversies over patent rights, and stories of patients who participated in the studies are described. One of the most interesting aspects is the detailed description of clinical trials and the interaction between researchers, patients, and regulatory agencies. It is a testament to the collective effort to bring an innovative treatment to those who needed it most.\u003c\/p\u003e\u003ch2\u003eImpact on medicine and lessons learned\u003c\/h2\u003e\u003cp\u003eHerceptin not only improved the survival of many women with HER2-positive breast cancer but also laid the groundwork for personalized medicine in oncology. The book reflects on how this case illustrates the importance of collaboration between academia, industry, and regulators. It also addresses the role of patient activism in accelerating approval processes. Herceptin's legacy goes beyond its therapeutic benefits: it established a model for the development of other targeted drugs, such as trastuzumab emtansine (T-DM1) and pertuzumab. For anyone interested in the history of oncology, this work offers a privileged insight into a therapeutic milestone.\u003c\/p\u003e\u003ch2\u003eAbout the author\u003c\/h2\u003e\u003cp\u003eRobert Bazell is a science journalist with extensive experience covering medical advances. He has worked for major media outlets such as NBC News and has closely followed the development of Herceptin. His clear, rigorous, and accessible style makes the book understandable to a wide audience, without sacrificing scientific depth.\u003c\/p\u003e\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\u003ch3\u003eDoes this book contain very complex technical information?\u003c\/h3\u003e\u003cp\u003eAlthough it addresses scientific concepts, the author uses accessible language for the general public. Key terms are explained and excessive jargon is avoided, making it understandable without prior medical training.\u003c\/p\u003e\u003ch3\u003eDoes the book include patient testimonials?\u003c\/h3\u003e\u003cp\u003eYes, it includes accounts from patients who participated in clinical trials and from doctors who drove the research. However, the main focus is the narrative of scientific development.\u003c\/p\u003e\u003ch3\u003eIs it useful for patients diagnosed with HER2-positive breast cancer?\u003c\/h3\u003e\u003cp\u003eIt can be very helpful for understanding the treatment they receive or will receive, as well as for knowing the historical and scientific context of Herceptin. However, it does not replace personalized medical advice.\u003c\/p\u003e","brand":"Random House","offers":[{"title":"Default Title","offer_id":48758937649306,"sku":null,"price":37.73,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0761\/4831\/0170\/files\/51TxrJHARML._SL1200_2c4683f8-da90-42b5-9e74-f49ea8cd60a0.jpg?v=1784306139","url":"https:\/\/vitaminaspain.es\/es\/products\/her-2-la-creacion-de-herceptin-tratamiento-revolucionario-cancer-de-mama-0812991842","provider":"vitaminaspain","version":"1.0","type":"link"}